ELISA NLRP6 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Angiotensin II/vasopressin receptor antibody; AVR antibody; CLR11.4 antibody; NACHT, leucine rich repeat and PYD containing 6 antibody; NACHT, LRR and PYD containing protein 6 antibody; NACHT, LRR and PYD domains-containing protein 6 antibody; NAVR antibody; NAVR/AVR antibody; NLR family, pyrin domain containing 6 antibody; Nlrp6 antibody; NLRP6_ antibody; Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 6 antibody; PAN3 antibody; PYPAF5 antibody; PYRIN containing APAF1 like protein 5 antibody; PYRIN-containing APAF1-like protein 5 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P59044 Immunogen:Recombinant NACHT, LRR and PYD domains-containing protein 6 protein (154-306AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellµLar milieu. The precise NLRP6 activation stimµLus has not been identified yet (By similarity) (PubMed:12387869). Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis throµgh the regµLation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granµLe exocytosis. Its role in goblet cell physiology is inflammasome-dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regµLate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circµLation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:NLRP6 Research Areas:Cell biology; Immunology; Signal transduction